We are grateful to all of the authors and contributors to this text for their time and consideration. It is our hope that this work will be the foundation for the future of MIS total hip and knee arthroplasty. Handbook of Pediatric Orthopedics. Paul D Sponseller. Master Techniques in Orthopaedic Surgery: Fractures. Donald Wiss.
Atlas of Airway Management. Steven L. Diana Gaitini. Richard L Angelo. Constantine T. Management of Complications in Oral and Maxillofacial Surgery. Michael Miloro. Emil Schemitsch. Kirby I. Atlas of Procedures in Neonatology. Mhairi G. Romeo Vecht. Introductory Guide to Cardiac Catheterization. Arman T. Andrew T. Ann L. Clinical Maxillary Sinus Elevation Surgery. Daniel W. Patrick J. Mansoor Kassim. Osteotomies around the Knee.
Philipp Lobenhoffer. Rotator Cuff Deficiency of the Shoulder. Mark A. Anatomy for problem solving in sports medicine: The Knee. Prof Philip F Harris. Essential Angioplasty. Respiratory Care Review. GARY A. Michael Pinzur. Franklin H.
Dominic Harmon. Operative Arthroscopy. Don Johnson. Gastrointestinal Endoscopy in Practice. Jean Marc Canard. The Multiple Ligament Injured Knee. Gregory C. Structural Heart Disease Interventions. John D. Terry Canale. Reverse Shoulder Arthroplasty. David M. Master Techniques in Surgery: Esophageal Surgery. James D. Elizabeth Hall-Findlay. Basics of Musculoskeletal Ultrasound. William W. Handbook of Craniomaxillofacial Surgery. James E Zins. Atlas of Temporomandibular Joint Surgery. Peter D. Darren L. Ear and Temporal Bone Surgery. Richard J. Julie Adams. Curbside Consultation in Fracture Management.
Walter Virkus. Vincent J. Grabb's Encyclopedia of Flaps: Head and Neck. Berish Strauch. Perforator Flaps for Breast Reconstruction. Joshua Levine. Bedside Procedures in the ICU. Florian Falter. Clinical Orthopaedic Rehabilitation E-Book.
Brent Brotzman. Atlas of Ultrasound-Guided Musculoskeletal Injections. Gerard Malanga. Procedures in Critical Care. William Hanson III. Alfredo Quinones-Hinojosa. Cerebral Revascularization: Microsurgical and Endovascular Techniques. Eric Nussbaum. James R. Sonoanatomy for Anaesthetists. Edward Lin. Surgical Solutions for Conductive Hearing Loss.
Mirko Tos. Talar Osteochondral Defects. Niek van Dijk. Bernard F. Bryan D. Alok Ranjan. Wang et al. Knee and hip OA is one of the leading causes of global disability and was ranked as the 11th highest contributor to global disability in the most recent Global Burden of Disease study in [ 2 ].
As such, OA as a disease results in large indirect costs to society, mostly driven by impacts on productivity [ 11 ]. These indirect costs, when coupled with rapid growth in direct healthcare related costs associated with management of the disease and specifically TJA as a major cost driver [ 12 ], mean that the economic burden is huge. Furthermore, it is likely to be exacerbated by the aforementioned growing obesity and OA prevalence.
Despite TJA being a very effective and cost-effective treatment option for end stage hip and knee OA, data from the Organisation for Economic Co-operation and Development OECD highlights continuing growth in the number of procedures being carried out with faster growth in knee replacements TKA particularly in countries with higher rates of overweight and obesity such as Australia, USA and the UK.
It has been estimated that in in Australia, allocated health care expenditure on OA alone was approximately AUD 2 billion [ 13 ]. However, given that obesity rates are likely to continue to rise, this will potentially lead to substantial increases in the prevalence of OA and an even greater burden on health care expenditure [ 13 ].
There is now a substantial body of evidence focusing on the relationship between obesity and OA from a variety of perspectives.
This includes investigation of the causal relationships of obesity and OA through biomechanical [ 14 ], physiological [ 15 ] and inflammatory mechanisms [ 16 ] and quantification of the impact of obesity on OA outcomes [ 14 ]. A recent review focused on addressing obesity in knee OA, identified 9 randomised controlled trials of weight loss interventions in people with knee OA. It concluded that there are several strategies likely to be successful in the management of knee OA [ 18 ]. However, the evidence base is far from definitive in terms of what is the most efficacious type of intervention, who it should specifically target and when along the treatment pathway it should be offered.
There are the usual challenges of whether obesity interventions can achieve long term weight maintenance and prevent weight regain [ 19 ], particularly in a population where OA symptoms may hinder physical activity efforts. There is also some concern that interventions that target weight loss alone may lead to muscle weakness and some bone density loss [ 20 ], meaning that an intervention that targets both weight loss and appropriate physical activity simultaneously is likely to be more favourable. This is reflected in current treatment guidelines recommending that weight maintenance and exercise in combination are suitable for managing OA symptoms [ 21 , 22 ], although, in reality, it is often difficult to determine compliance with these recommendations.
Despite this apparent research momentum, it is not clear what the contribution of research from a health economics perspective has been in terms of supporting the use of obesity interventions in the prevention or management of OA. Health economists typically carry out two different types of studies designed to achieve different purposes. Firstly, they describe and predict the economic impact of a disease or risk factor in order to quantify its cost burden commonly known as cost of illness studies ; secondly, they evaluate the incremental costs and benefits of alternative options to current practice cost-effectiveness studies [ 24 ] to inform resource allocation decisions.
The latter essentially addresses the main objective of economics per se, that being efficiency, or maximising the benefit from available resources. The goals of this study are two-fold. Firstly, it aims to identify and review the published economic evidence that is focused on describing and quantifying the economic impact of obesity in OA populations. Secondly, it reviews economic evaluations of interventions designed to explicitly address obesity in OA populations in order to prevent the onset of OA or improve OA clinical outcomes and potentially health related quality of life HrQoL , to determine which interventions represent value for money.
In doing so, the study also highlight gaps in the literature and identifies future priorities for this burgeoning area of research. A systematic search of the published peer reviewed literature was conducted in July, by the lead author. The search was limited to full text literature published in the English language from January — July A targeted Google search of the grey literature using the search terms was conducted, plus the reference lists of all relevant articles were searched for further studies.
Titles and abstracts were searched and relevant full -articles, extracted and reviewed see flow chart, Fig. For inclusion, studies had to fulfil one or more of the three following broad criteria:. A costing or cost of illness study which evaluates the association of obesity in any OA study population with healthcare or other societal costs. A partial economic evaluation study which assesses either the costs alone or the costs and outcomes of an obesity intervention in any OA study population but without comparison to an alternative healthcare pathway cost description or cost-outcome description or where the costs of alternatives are examined but without consideration of outcomes simultaneously cost analysis.
An obesity intervention was defined as any intervention that included a component that addressed weight loss or weight maintenance in order to impact on OA symptoms and outcomes. A full economic evaluation study such as a cost-effectiveness analysis, cost utility analysis or cost benefit analysis which assesses both the costs and benefits of an obesity intervention against a known alternative or usual care in any OA study population. The three criteria were purposely broad given that this is a scoping review designed to find any relevant studies and highlight gaps in the literature.
In the first instance, citations were retrieved from searched databases and other sources After removal of duplicates and irrelevant citations, abstracts of candidate articles were screened of which 71 full text articles were assessed for eligibility. There were twelve studies identified as cost burden studies; they all included analysis of the association between the presence of obesity in total joint replacement populations used as a predictor of healthcare costs [ 25 — 36 ]. The remaining three studies were set in inpatient rehabilitation hospitals with two studies focusing on TKA recipients [ 27 , 29 ] and one on THA recipients [ 28 ].
They included a mix of studies focusing on primary or index TJA surgery only [ 25 , 26 , 30 — 33 ] or inclusion of both primary and revision types of surgeries [ 27 — 29 , 34 — 36 ]. This highlights the heterogeneity between studies in relation to the specific populations under study, with each having its own unique set of patient inclusion and exclusion criteria. Nearly all studies were conducted in the USA with only one study conducted in Australia [ 33 ]. All studies, regardless of setting, were conducted retrospectively from a narrow healthcare perspective and were restricted to the collection of direct medical costs or charges specific only to that setting.
All studies relied on hospital administration data. While this enabled most of the studies to have near complete data, the downside was that the costs reported in each study were limited and did not reflect the total cost burden. As an example, the studies conducted in the acute care setting took no account of costs of the resources consumed in rehabilitation, supportive nursing facilities, outpatient and ambulatory care services or costs borne either by other sectors or by patients themselves.
Methods used for identification, measurement and reporting of cost outcomes were heterogeneous and not always transparent; some studies provided little detail about their costing methodology including the selection or specification of cost items included in reported aggregate resource use [ 27 , 28 , 32 ] or the reference year used for the costing [ 27 , 28 ]. Some studies only presented hospital charges rather than costs per se [ 26 — 29 ], the former usually reflecting an element of profit as well as a method of recouping uncompensated costs.
If this profit is considered above and beyond the societal opportunity cost, then adjustments should be made with cost to charge ratios [ 37 ].
However the choice of ratio applied eg. The timeframe over which resource use was measured also varied greatly between studies. Some studies only accounted for hospital resource use during inpatient stay post -surgery [ 25 — 29 , 32 ]. The studies varied in terms of ascertaining and classifying the presence of obesity in the study population. Nearly all identified studies used recorded height and weight data obtained from medical records as the basis of BMI calculations.
However the Kim et al. This opened the study to misclassification bias and it has also been suggested in the literature that administrative data underreports the presence of obesity [ 36 ]. The main variation in analytical approach between studies was whether an analysis conducted accounted for the presence of obesity related co-morbidities as a potential mediator or confounder between obesity and hospital costs.
More recent studies were more likely to present results of both unadjusted and adjusted analyses using well known comorbidity indexes to show both the mediated and independent effect of obesity on hospital costs. Kremers et al [ 35 ], stated that obesity is a risk factor for several costly comorbidities and, therefore, controlling for co-morbidities may result in underestimation of the true incremental cost of obesity because costs attributable to comorbidities theoretically can be considered attributable to obesity.
Given such heterogeneity in elements of study design, including study setting, sample size, population under study, measurement of key variables and the analysis performed, it is not surprising that results of those studies are somewhat mixed. Three studies suggest there is no difference between groups by BMI categories on hospital costs in the acute care setting [ 26 , 30 , 31 ]. Overall, the more recent studies, with larger sample sizes and longer follow up periods tended to present positive association results.
The main driver of the cost difference was overall hospitalisation costs, although length of stay LOS related to the primary episode of care, was not always identified as a contributing factor to these higher costs. Whilst Epstein et al. The two single centre rehabilitation studies [ 27 , 28 ] reported that severe obesity in both THA and TKA populations was associated with higher overall hospital charges.
However, results of the much larger multicentre trial in the TKA population contradicted the results of the single site study by reporting that whilst the severely obese had the highest daily charges of all BMI groups albeit modest at USD per day , total charges were highest in the non obese group. The authors cautioned interpretation of these results, given that the average non obese patient was The authors also reported a significant interaction effect between high BMI and revision surgery leading to prolonged and more costly inpatient care.
Results of the literature search revealed only one full economic evaluation. The study provides evidence that a multimodal intervention incorporating both physical activity and diet components is the most efficient choice for improving self-reported function, pain and stiffness as measured using the 3 Western Ontario and McMaster Universities Osteoarthritis Index WOMAC. However, it was not the most efficient choice for weight loss alone or for functional measures of mobility alone.
The authors suggest that the magnitude of change in WOMAC scores found in the exercise and diet group could be considered clinically significant in similar Knee OA populations [ 38 ]. While the authors concluded that both weight loss and physical activity are needed to achieve improvements in subjective physical function and pain, it is not clear whether a diluted approach would necessarily achieve the same results.
There are some limitations to this study that are acknowledged by the authors. Costing was performed from a narrow managed care as health care provider perspective. For example, it did not include patient out of pocket costs such as the cost of pharmaceuticals which are likely to be impacted, particularly if pain and function is improved by the intervention. Other costs that would be included from a societal perspective such as productivity impacts were likewise excluded. The time horizon was also limited to the duration of the trial. Longer term follow up of both costs and outcomes would have provided greater understanding of whether the intervention could maintain function in the long term, prevent disease progression and the associated impact on healthcare resource use over this time.
Despite a growing body of literature highlighting the importance of addressing obesity in OA populations, this review highlights the current paucity of economic evaluation research conducted in this area. Therefore, it remains unclear as to whether it is efficient to address obesity explicitly for the prevention or management of OA, how to best do it, which population to target, and when along the disease spectrum this should occur.
Nearly all studies identified were cost burden studies in TJA populations conducted to assess whether obesity leads to higher healthcare sector costs. It should also be noted that all of identified the studies related to OA in knees and hips, despite the search of OA being much broader. All of the costing studies adopted the narrow perspective of the individual healthcare setting from which the main cost data were derived; therefore, they did not account for costs associated with the whole continuum of care for TJA and only provided a snapshot of the potential economic impact compared to if a societal approach had been taken.
With greater streamlining of acute health care clinical pathways for joint replacement recipients, some of the traditional post-operative costs have shifted away from the acute care setting and onto inpatient rehabilitation, outpatient, community and ambulatory care settings as well as patients and families themselves.
ISBN 13: 9780387403533
Ideally, resource use should be tracked throughout the whole episode of care, using database linkage to gain a broader understanding of the costs associated with the presence of obesity in TJA populations. A Canadian study by Tarride et al [ 44 ] which tracked total healthcare resource use in both hospital and ambulatory care settings though not OA attributable costs per se , demonstrated that healthcare costs per year to OA patients were nearly double those of non OA control participants.
A subsequent finding that was not the primary objective of the study was that costs were more than triple for obese OA patients compared to non-obese controls; this highlights that the co-existence of obesity and OA possibly augments the excess financial burden of OA. Not all of the costing studies reviewed concluded that higher costs in TJA populations were due to obesity per se.
However, the more recent studies with stronger methodologies trended towards showing significant differences in healthcare costs between the severely obese compared to other BMI categories, which suggests that there are potential health care cost savings to be realised if weight loss in the severely obese is addressed prior to TJA surgery. Similarly, establishing and subsequently investing in interventions with proven efficacy alone without consideration of the cost implications will inevitably drive healthcare spending upwards [ 45 ]. Lap band surgery is highly efficacious [ 49 , 50 ] and cost-effective [ 50 , 51 ] as a weight loss intervention in the severely obese but it is also a very costly intervention.
It remains to be seen whether the incremental cost of adding this procedure prior to TJA in this population is outweighed by the incremental benefits achieved through cost offsets and improved health outcomes including health related quality of life gains immediately post-surgery and over longer time periods. It is certainly worthy of further investigation however, given evidence of the association of pre-operative obesity predicting additional weight gain post TJA [ 52 ] which is only likely to further precipitate the ill effects of OA and obesity in combination.
Only one economic evaluation was identified in this review [ 38 ]. This showed that despite a small but growing number of efficacy trials that have been conducted to assess the impact of interventions to address obesity in OA populations [ 18 ], published cost-effectiveness studies are still lacking as in many areas of obesity research. The Sevick et al study, provided some evidence that weight loss and exercise in combination was most cost-effective in improving pain and function in overweight and obese patients with moderate knee OA compared to only exercise or weight loss independently.
It would be of particular interest to a range of stakeholders clinicians, funders and patients to know if the intervention was able to slow disease progression, control symptoms and maintain function for longer in persons with obesity and OA and subsequently delay their demand for more intensive and costly healthcare that coincides with higher levels of disability.
Longer term cost-effectiveness studies however are reliant on either longer duration efficacy studies being conducted or, alternately, extrapolation of outcomes through modelling; the latter can be very informative but are dependent on assumptions especially in relation to maintenance of program effect. It would also be interesting to see how changes in OA symptoms as a result of an intervention manifests in terms of the quality of life impact using a utility-based HRQoL measure that can be used in economic evaluation to produce a cost per Quality Adjusted Life Year QALY.
QALYs provide a common generic measure of benefit taking into account both mortality and morbidity impacts and importantly, within this context, may capture benefit from weight loss and exercise that extends beyond that of the effect on immediate OA related outcomes. This metric also facilitates comparison of the cost effectiveness of interventions within and across disease areas.
Even if studies have not incorporated a generic utility based HRQoL measure, there are reliable mapping techniques available. With only one published cost-effectiveness study to inform policy and practice in this area, it is evident that there is a need for more economic evaluations of interventions to be conducted. This is inherently reliant on a growing evidence base of the efficacy of such interventions which ideally would incorporate economic evaluation alongside such efforts. Modeling could then be utilised to predict longer term cost-effectiveness over the life course and OA disease progression; this would require explicit statements of the assumptions about maintenance of program effect and their testing in sensitivity analysis.
Economic evaluation in addressing obesity in OA should ideally adopt a societal perspective given that both costs and benefits may be incurred beyond the heath-care sector and where possible, an incremental cost per QALY should be reported to provide comparison across disease areas. The notion of intervening to alter disease progression, delay, avoid or reduce complications post TJA by addressing obesity explicitly is, prima facie, likely to have both downstream economic and health benefits to healthcare systems, individuals and society as a whole.
In practice, guidelines identify the need to focus on obesity in the management of OA, however it is evident that there is a lack of data both from an efficacy and cost-effectiveness perspective to support and to guide to whom, how and when this should be conducted and whether it should be explicitly incorporated into clinical pathways and public health practice.
MIS of the Hip and the Knee - A Clinical Perspective | Giles R. Scuderi | Springer
More research is therefore warranted in order to guide clinicians, funders, decision makers and patients alike. Overall, this review has demonstrated that while the presence of obesity in OA populations, and in particular severe obesity, has been shown to have significant health and economic impacts, there is a dearth of evidence from an economic perspective to guide resource decisions about whether addressing obesity explicitly is considered value for money.
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MIS of the Hip and the Knee: A Clinical Perspective
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